Advanced Technology for Motor Neurophysiology

By developing advanced nanofabrication tools for manufacturing ultra-dense, ultra-flexible electrode arrays, we are creating a new class of electromyography (EMG) electrodes capable of recording large populations of single-unit recordings from muscle fibers during behavior.

Flexible EMG arrays with integrated electronics for scalable electrode density
Anschutz PM, Zia M, Lu J, Williams MJ, Jacob AL, Sober SJ, Bakir MS. BioRxiv preprint 2024.07. 02.601782 (2024) [PDF] [DOI]

---

Opto-Myomatrix: μLED integrated microelectrode arrays for optogenetic activation and electrical recording in muscle tissue
Lu J, Zia M, Baig DA, Yan G, Kim JJ, Nagapudi K, Anschutz P, Oh S, O'Connor DH, Sober SJ, Bakir MS. BioRxiv preprint 2024.07. 01.601601 (2024) [PDF] [DOI]

---

Myo-optogenetics: optogenetic stimulation and electrical recording in skeletal muscles
Kim JJ, Wyche IS, Olson W, Lu J, Bakir MS, Sober SJ, O'Connor DH. BioRxiv preprint 2024.06. 21.600113 (2024) [PDF] [DOI]

---

Myomatrix arrays for high-definition muscle recording
Chung B, Zia M, Thomas KA, Michaels JA, Jacob A, Pack A, Williams MJ, Nagapudi K, Teng LH, Arrambide E, Ouellette L, Oey N, Gibbs R, Anschutz P, Lu J, Wu Y, Kashefi M, Oya T, Kersten R, Mosberger AC, O'Connell S, Wang R, Marques H, Mendes AR, Lenschow C, Kondakath G, Kim JJ, Olson W, Quinn KN, Perkins P, Gatto G, Thanawalla A, Coltman S, Kim T, Smith T, Binder-Markey B, Zaback M, Thompson CK, Giszter S, Person A, Goulding M, Azim E, Thakor N, O'Connor D, Trimmer B, Lima SQ, Carey MR, Pandarinath. ELife 12:RP88551 (2023) [PDF] [DOI]

Commentary

Accessing populations of motor units
Kirk EA, Sauerbrei BA. eLife 2024;13:e94764. (2024) [PDF] [DOI]

---

Fabrication and Characterization of 3D Multi-Electrode Array on Flexible Substrate for In Vivo EMG Recording from Expiratory Muscle of Songbird
Zia M, Chung B, Sober SJ, Bakir M. Proceedings IEEE International Electron Devices Meeting San Francisco, CA (2018) [PDF]

---

Motor control by precisely timed spike patterns
Srivastava K, Holmes CM, Vellema M, Pack A, Elemans C, Nemenman I, Sober SJ. Proceedings of the National Academy of Sciences 114(5):1171-1176 (2017) [PDF]

---